Reduce Cognitive Deficits: Try Polygala tenuifolia Extract

Polygala tenuifolia extract may reduce cognitive deficits - sold by Linden Botanicals.

Polygala tenuifolia extract may reduce cognitive deficits according to a study in BMC Complementary Medicine and Therapies.

Polygala tenuifolia is a traditional Chinese medicine with multiple neuroprotective effects. The recent study investigated the effects of three active constituents [3,6′-disinapoyl sucrose (DISS), onjisaponin B (OB) and tenuifolin (TEN)] of Polygala tenuifolia on the proliferation and differentiation of neural stem cells (NSCs) to identify the potential active constituent of Polygala tenuifolia promoting hippocampal neurogenesis.

Polygala tenuifolia shows significant potential in helping to reduce cognitive deficits. The study’s findings, published in October 2021, demonstrated that DISS is the active constituent of Polygala tenuifolia that triggers the most potent increase of hippocampal neurogenesis.

Alzheimer’s disease is the most common dementia worldwide, and there is still no satisfactory drug or therapeutic strategy. The study’s results may have important implications for future treatment of Alzheimer’s disease.

Polygala tenuifolia May Reduce Cognitive Deficits

Polygala tenuifolia, also known as Yuan Zhi, is one of the 50 fundamental herbs used in traditional Chinese medicine. It’s thought that it may empower the sleep process by discharging repressed emotions and relaxing the body. It’s often recommended for geriatric concerns because of its potential ability to improve memory, reduce cognitive deficits, and protect against cognitive ailments.

Buddhist monks have long used Polygala tenuifolia to support meditation and focus. Beyond brain and mood support, it has been used to support treatment of inflammation of the throat, nose, and chest and for lung conditions including asthma, chronic bronchitis, whooping cough and emphysema. The root is considered antibacterial, cardiotonic, cerebrotonic, expectorant, haemolytic, hypotensive, sedative and tonic.

Many studies, including a study published in Neurochemical Research Journal, suggest that Polygala tenuifolia may go beyond simply being neuroprotective and may reduce cognitive deficits by promoting neural stem cell proliferation and differentiation, pushing the plant into a special category of nootropics that support new brain cell growth.

Try Polygala tenuifolia Extract

Known as the “will strengthener,” Polygala tenuifolia is thought to relax the soul, calm the heart, and ease restlessness and anxiety. Adherents believe it improves creative thinking and enhances dreaming and manifested ideas. The Chinese name “Yuan Zhi” translates to “high aspirations.” It is valued for its potential ability to reduce cognitive deficits and provide protection to the brain.

To learn more about the possible health benefits of Polygala tenuifolia extract, a good place to start is with the Polygala FAQ. Linden Botanicals sells Polygala tenuifolia extract in its online store.

Read the FAQ Buy Polygala Now


Linden Botanicals sells the world’s healthiest teas and extracts, including Polygala tenuifolia, Cryptolepis sanguinolenta, Cistus incanus, Phyllanthus niruri, and Cistanche tubulosa. These teas and extracts provide support for brain health, immune health, stress relief, energy, memory, mood, kidney health, joint health, digestive health, inflammation, hormonal balance, and detox/cleanse. The company’s website,, includes hundreds of valuable health tips and resources and the free Lessons from the Darkness e-book, which chronicles Michael Van der Linden’s four-year battle with Lyme disease.

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