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Natural Antidepressant Herbs: Recent Studies Point to Cistanche Extract

Cistanche tubulosa - Natural Antidepressant Herbs - Linden Botanicals

Cistanche tubulosa extract, one of the best natural antidepressant herbs, offers anti-aging, anti-fatigue, neuroprotective, and antidepressant properties.


Natural Antidepressant Herbs: Cistanche

recent study in Frontiers in Pharmacology suggests Cistanche tubulosa extract demonstrates antidepressant-like effects on chronic stress. The study addresses the health benefits of Cistanche tubulosa extract, including its antidepressant-like effects through its ability to restore gut microbiota homeostasis.

In the study, a chronic unpredictable stress-induced depression model was established to explore the impact of Cistanche tubulosa extract on behavioral tests and gut microbiota composition. The study reviews both antidepressant drugs and natural antidepressant herbs and concludes that Cistanche is “a potential treatment for depressive symptoms by restoring homeostasis of gut microbiota for microbiota–gut–brain axis disorders, opening new avenues in the field of neuropsychopharmacology.”

Growing evidence shows that neuropsychiatric disorders, such as depression, are linked to the gut microbiome through the gut–brain axis. Cistanche tubulosa extract is well known for supporting the treatment of “kidney-yang” deficiency in traditional Chinese medicine. In recent years, an extract made of the plant has increasingly been used to support treatment of neurodegenerative diseases.

Cistanche tubulosa Extract Benefits

Cistanche tubulosa extract offers many benefits due to its anti-aging, anti-fatigue, antimicrobial, anti-inflammatory, hepatoprotective, immunological, cardiovascular, and antioxidant properties. Linden Botanicals calls Cistanche “Methuselah’s Breakfast.” In the Bible, Methuselah lived until the ripe old age of 969, making him the longest-lived human in both legend and tradition.

Pharmacological analysis has shown that Cistanche extract exhibits a broad range of neuroprotective, immunomodulatory, anti-inflammatory, and hepatoprotective activities.

Natural antidepressant herbs like Cistanche tubulosa show great promise for clinical application, not only because of its antidepressant-like activity but also because it has traditionally been used to treat impotence.

Learn More About Cistanche Extract

Native to Mongolia, Cistanche tubulosa is a parasitic flower that has been used in traditional Chinese medicine for thousands of years. It’s a nootropic and an adaptogen also known by the names Cistanche deserticola, desert ginseng, and Rou Cong Rong. In addition to being one of the best natural antidepressant herbs, Cistanche is an extremely strong antioxidant. It is 15 times stronger than resveratrol and 5 times stronger than vitamin C.

There is good reason to believe that a lifestyle-related approach to optimal health will benefit from support with Cistanche extract as a health supplement.

Linden Botanicals sells Cistanche extract in small 100 gram sizes as OOMPH! energy support and in larger sizes of 200 to 1,000 grams. To learn more about Cistanche tubulosa, a good place to start is our Cistanche FAQ and this study, along with dozens of studies in the National Center for Biotechnology Information (NCBI) database.

Read the FAQ Buy OOMPH! Buy Cistanche


Linden Botanicals sell the world’s healthiest teas and extracts, including natural antidepressant herbs. These teas and extracts provide support for immune health, stress relief, energy, memory, mood, kidney health, joint health, digestive health, inflammation, hormonal balance, and detox/cleanse.

Visit to shop the online store, get hundreds of valuable health tips and resources, and download the free Lessons from the Darkness e-book, which chronicles Linden Botanicals owner Michael Van der Linden’s four-year battle with Lyme disease.

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